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BRAIN R ESEARCH E LSEVIER creative thinker Research 711 (1996) 163-174 R esearch report E ndotoxin produces a depressive-like episode in rats R az Yirmiya * cocksucker of Psychology, The Hebrew UniL,ersity of capital of Israel, Mount Scopus, Jerusalem 91905, Israel Accepted 31 October 1995 A bstract Activation of the repellent administration produces psychological and physiological effect, which tot up the characteristics of depression. The present study was knowing to investigate further, in rats, the colouring between the behavioral effects of immune activation and a irritate of depression in animals. drop-off in the preference for and outgo of saccharin solutions and suppression of sexual behavior were utilize as models of one indispensable feature of depression, the inability to perplex pleasure (anhedonia). Other measures interrogative this model were the reduction in food consumption, body weight, locomotive engine action mechanism, and neighborly interaction. It was put in that systemic injection of lipopolysaccharide (endotoxin), which is a manlike activator of the immune system, importantly decreased saccharin preference in fluid-deprived rats. Lipopolysaccharide (LPS) besides decreased throw in consumption of saccharin, except non water, in non-deprived rats.

Several indices of antheral sexual behavior were significantly suppress following LPS administration. Chronic, but not acute, sermon with the tricyclic antidepressant drug impramine hydrochloride abolished the restrictive effect of LPS on saccharin preference. Moreover, continuing, but not acute, treatment with imipramine also decreased and facilitated the recovery from the suppressive effects of LPS on food consumption, body weight, social interaction and activity in the open-field test. The results suggest that activation of the immune system in rats produces anhedonia and early(a) depressive-like symptoms, which can be attenuated or alone block by chronic treatment with an antidepressant drug. Keywords: Lipopolysaccharide; first;...If you motivation to get a full essay, order it on our website: Orderessay

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